simFastBOIN: Fast Bayesian Optimal Interval Design for Phase I Dose-Finding Trials

Conducting Bayesian Optimal Interval (BOIN) design for phase I dose-finding trials. 'simFastBOIN' provides functions for pre-computing decision tables, conducting trial simulations, and evaluating operating characteristics. The package uses vectorized operations and the Iso::pava() function for isotonic regression to achieve efficient performance while maintaining full compatibility with BOIN methodology. Version 1.3.2 adds p_saf and p_tox parameters for customizable safety and toxicity thresholds. Version 1.3.1 fixes Date field. Version 1.2.1 adds comprehensive 'roxygen2' documentation and enhanced print formatting with flexible table output options. Version 1.2.0 integrated C-based PAVA for isotonic regression. Version 1.1.0 introduced conservative MTD selection (boundMTD) and flexible early stopping rules (n_earlystop_rule). Methods are described in Liu and Yuan (2015) <doi:10.1111/rssc.12089>.

Version: 1.3.2
Imports: knitr, kableExtra, Iso, stats
Suggests: testthat (≥ 3.0.0), rmarkdown
Published: 2025-12-17
DOI: 10.32614/CRAN.package.simFastBOIN (may not be active yet)
Author: Gosuke Homma ORCID iD [aut, cre]
Maintainer: Gosuke Homma <my.name.is.gosuke at gmail.com>
BugReports: https://github.com/gosukehommaEX/simFastBOIN/issues
License: MIT + file LICENSE
URL: https://github.com/gosukehommaEX/simFastBOIN
NeedsCompilation: no
Language: en-US
Materials: README, NEWS
CRAN checks: simFastBOIN results

Documentation:

Reference manual: simFastBOIN.html , simFastBOIN.pdf
Vignettes: Introduction to simFastBOIN (source, R code)

Downloads:

Package source: simFastBOIN_1.3.2.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available

Linking:

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