Changes in version 1.1.4: o Updated vignette. Equality constraints on GABA shunt and pentose phosphate pathway fluxes are now used in FBA and ensemble simulations. Changes in version 1.1.3: o Updated vignette and bibtex file. FBA and ensemble sampling are now done with integration of brain metabolite uptake measurement data. o Added new function 'sampleFluxEnsemble' which can be used to generate a posterior distribution of flux vectors with respect to measuerement error in certain fluxes. An example of 'sampleFluxEnsemble' has been added to the package vignette. o Added LIM model file 'Glycolysis_TCA.LIM' to the examples directory. This file contains the model which is build in the examples. o Fixed warnings in functions buildSBMLFromReactionIDs and createLIMFromSBML to seperate missing identifiers with a comma. Changes in version 0.99.3: o Initial release of BiGGR in Bioconductor. Package was formerly available on CRAN.