LTFHPlus: Implementation of LT-FH++
Implementation of LT-FH++, an extension of
the liability threshold family history (LT-FH) model.
LT-FH++ uses a Gibbs sampler for sampling from the truncated
multivariate normal distribution and allows for
flexible family structures. LT-FH++ was first described in
Pedersen, Emil M., et al. (2022)
<doi:10.1016/j.ajhg.2022.01.009>
as an extension to LT-FH with more flexible family structures,
and again as the age-dependent liability threshold (ADuLT) model
Pedersen, Emil M., et al. (2023)
<https://www.nature.com/articles/s41467-023-41210-z>
as an alternative to traditional time-to-event genome-wide
association studies, where family history was not considered.
| Version: |
2.1.4 |
| Imports: |
batchmeans, dplyr, future.apply, future, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr |
| LinkingTo: |
Rcpp |
| Suggests: |
MASS, knitr, rmarkdown, kinship2, testthat |
| Published: |
2025-05-26 |
| DOI: |
10.32614/CRAN.package.LTFHPlus |
| Author: |
Emil Michael Pedersen [aut, cre],
Florian Privé [aut, ths],
Bjarni Jóhann Vilhjálmsson [ths],
Esben Agerbo [ths],
Jette Steinbach [aut],
Lucas Rasmussen [ctb] |
| Maintainer: |
Emil Michael Pedersen <emp at ph.au.dk> |
| BugReports: |
https://github.com/EmilMiP/LTFHPlus/issues |
| License: |
GPL-3 |
| URL: |
https://github.com/EmilMiP/LTFHPlus |
| NeedsCompilation: |
yes |
| Language: |
en-GB |
| Materials: |
README, NEWS |
| CRAN checks: |
LTFHPlus results |
Documentation:
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