TrialEmulation: Causal Analysis of Observational Time-to-Event Data
Implements target trial emulation methods to apply randomized clinical trial design and analysis in an observational setting. Using marginal structural models, it can estimate intention-to-treat and per-protocol effects in emulated trials using electronic health records. A description and application of the method can be found in Danaei et al (2013) <doi:10.1177/0962280211403603>.
| Version: | 0.0.4.5 |
| Depends: | R (≥ 4.1.0) |
| Imports: | broom (≥ 0.7.10), checkmate, data.table (≥ 1.9.8), DBI, duckdb, formula.tools, lifecycle, lmtest, methods, mvtnorm, parglm, Rcpp, sandwich |
| LinkingTo: | Rcpp |
| Suggests: | knitr, parsnip, rmarkdown, rpart, testthat (≥ 3.0.0), withr |
| Published: | 2025-06-13 |
| DOI: | 10.32614/CRAN.package.TrialEmulation |
| Author: | Isaac Gravestock 
[aut, cre],
Li Su [aut],
Roonak Rezvani
[aut] (Original package author),
Julia Moesch [aut],
Medical Research Council (MRC) [fnd],
F. Hoffmann-La Roche AG [cph, fnd] |
| Maintainer: | Isaac Gravestock <isaac.gravestock at roche.com> |
| BugReports: | https://github.com/Causal-LDA/TrialEmulation/issues |
| License: | Apache License (≥ 2) |
| URL: | https://causal-lda.github.io/TrialEmulation/, https://github.com/Causal-LDA/TrialEmulation |
| NeedsCompilation: | yes |
| Language: | en-GB |
| Materials: | README, NEWS |
| CRAN checks: | TrialEmulation results |
Documentation:
| Reference manual: | TrialEmulation.html , TrialEmulation.pdf |
| Vignettes: |
Extending-TrialEmulation (source, R code) Getting-Started (source, R code) New Interface (source, R code) |
Downloads:
| Package source: | TrialEmulation_0.0.4.5.tar.gz |
| Windows binaries: | r-devel: TrialEmulation_0.0.4.5.zip, r-release: TrialEmulation_0.0.4.5.zip, r-oldrel: TrialEmulation_0.0.4.5.zip |
| macOS binaries: | r-release (arm64): TrialEmulation_0.0.4.5.tgz, r-oldrel (arm64): TrialEmulation_0.0.4.5.tgz, r-release (x86_64): TrialEmulation_0.0.4.5.tgz, r-oldrel (x86_64): TrialEmulation_0.0.4.5.tgz |
| Old sources: | TrialEmulation archive |
Linking:
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