hce 0.8.5
- Added an implementation summaryWO.adhce()to provide
the summaries byGROUP, as opposed tosummaryWO.hce(), which works without grouping by this
variable.
- Details have been added regarding the implementation of the
simKHCE()function. The function has been updated to return
all time-to-event outcomes for each patient in theADETdataset.
- A bug has been fixed in regWO(), which previously
caused the results to depend on the order of the input dataset. This
issue also affected thestratWO()function, since it callsregWO(). A similar issue in theIWP()has also
been fixed. The bug was reported by Cyrill Scheidegger.
- The hce()function has been for consistency with theas_hce()function. Two new arguments,PADYandAVAL0, have been added. ThePADYargument
serves a similar purpose as now-deprecatedORDargument.
With these updates,hce()can produce outputs of classadhcewhen theAVAL0argument is
provided.
- Examples have been added to the calcWINS()implementation to illustrate the differences between the following
formulas for the standard error of the win proportion: the
Bamber-Brunner-Konietschke formula (see Bamber, 1975; Brunner and
Konietschke, 2025), Brunner-Munzel test (Brunner and Munzel, 2000) based
on the DeLong-Clarke-Pearson (1988) formula, and the Somers (1962)
formula.
hce 0.8.0
- Fixed a bug in summaryWO.formula()that previously
caused errors whenGROUPvalues were used.
- The function simADHCE()has been replaced by theall_data = TRUEimplementation insimHCE().
- The function simHCE()now returns an object of a new
class calledadhce. This class inherits from thehceclass, which itself is a subclass ofdata.frame. The underlying structure of the returned object
remains unchanged. The introduction of theadhceclass is
intended to clearly distinguish these structured outputs from the more
generalhceobjects. Specifically, anadhceobject is an analysis-readyhceobject that is derived
using multiple time-to-event outcomes and a single continuous (ordinal
or score) endpoint.
- The function as_hce()has been updated to support
additional output flexibility. If the input data includes the variablesTRTP,GROUP,AVAL0, andPADY, the function will return anadhceobject. In this scenario, even if theAVALvariable is
present, it will be recalculated based on the provided data to ensure
consistency with theadhcestructure. If only theTRTPandAVALvariables are available,as_hce()will return a standardhceobject.
This enhancement allows users to generate either general or
analysis-readyhceobjects, depending on the available
input variables.
hce 0.7.2
- regWO()and- stratWO()are updated to
return the confidence interval for the adjusted and stratified (or
adjusted/stratified) win probability as well.
- Added the formula implementation of regWO().
hce 0.7.0
- plot()method for- hceobjects (created by
the function- as_hce()) is updated to include a- fillargument for filling the area above the graph.
- calcWINS()is updated to include the- SE_WP_Typeargument with default- "biased"(original implementation) and a new- "unbiased"implementation of the Bamber-Brunner-Konietschke (see Bamber (1975),
Brunner and Konietschke (2025)) standard error for the win
proportion.
- New function IWP()is added to calculated patient-level
individual win proportions.
- Default method for the generic as_hce()is added.
- The vignette on hierarchical composite endpoints is updated to
include the theoretical framework for the simulation of dependent
outcomes using the given copula.
- The function simHCE()is updated to correct for the
copula implementation so thattheta = 1(case of
independence) andthetaclose to 1 now give similar results
(as expected).
hce 0.6.7
- The function simHCE()is updated to include a newthetaargument for Gumbel dependence coefficient of the
Weibull distributions for time-to-event outcomes. Default istheta = 1which assumes independence of time-to-event
outcomes. The argument is still experimental.
- calcWO()is updated to return the confidence interval
for the win probability as well.
- plot()method for- hceobjects (created by
the function- as_hce()) is implemented to provide the
ordinal dominance graph as suggested by Bamber (1975).
hce 0.6.5
- The functions powerWO(), sizeWO(), minWO()are updated
to include a new argumentalternativeto specify the class
of alternative hypothesis. All formulas are based on the Bamber (1975)
paper.
- Added a new dataset COVID19plus.
hce 0.6.3
- Added a NEWS.mdfile to track changes to the
package.
- The hex sticker of the package has been created and is included in
all vignettes.
- HCE1 - HCE4datasest are updated to follow the standard
structure.
- A new argument decis added tosimHCE()for decimal places used for rounding the continuous outcome in the
simulated dataset. Additionally, the default value for the standard
deviation of the continuous variable in the placebo groupCSD_Pis changed to be equal to that of the active groupCSD_Ainstead of being equal to 1.
- A new function simADHCE()which simulatesadhceobjects, that is, anhceobject with its
source datasets. Works similar tosimHCE()which provides
only anhceobject.
- A new function simORD()which simulates ordinal
endpoint by categorizing beta distributions.